Journal: Journal of controlled release : official journal of the Controlled Release Society
Article Title: Strategies to Enhance the Distribution of Nanotherapeutics in the Brain
doi: 10.1016/j.jconrel.2017.07.028
Figure Lengend Snippet: PS-PEG (red) and PS-COOH (green) NP distribution in the striatum 1 hour post-administration vi a CED. White bold-arrow indicates direction of infusion. NP near the striate arteries were imaged following CED in (B) water, (C) 0.9% saline or (D) 3% saline. Blue represents cell nuclei (DAPI). Overlay of NP is represented as yellow. Relative distribution of NP fluorescence in PVS away from the striate artery following CED in (E) water, (F) 0.9% saline or (G) 3% saline. At least N = 3 striate vessels were quantified for each condition. (H) Percent coverage of NP fluorescence within the ICS calculated using image-based MATLAB quantification. Statistically significant differences are denoted by *p < 0.05.
Article Snippet: At least N = 3 striate vessels were quantified for each condition. (H) Percent coverage of NP fluorescence within the ICS calculated using image-based MATLAB quantification.
Techniques: Saline, Fluorescence